The Mureș superior region follows the river Mureș from the Transylvanian plain to its source in the eastern Carpathian mountains. There is very little archaeology in this area which suggests that this part of the Mureș valley was not an area which had been widely occupied by past civilisations.

The town of Reghin, at the lower part of this region, was previously Saxon and Hungarian, and has existed from at least the 13th century. To the south of Reghin the villages are mixed Hungarian, Romanian, Rom (gypsy) and Saxon, to the east is the Romanian Gurghiului region and to the north the Mureș superior region becomes predominantly Romanian.

High in the upper reaches of the Mureș, in the Carpathians is the Hungarian sub-zone of Gheogheni. The town was already established by 1332 and became prosperous during the 17th century. Although this town has a Szekely history the Hungarians in this region are now not Székely but from central Transylvania and live mainly in the villages along the main road from Reghin: Alunis, Vălenii de Mureș, Lunca Mureșului, Brâncovenestim and Suseni.